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netrin
Function:
- netrins function as axonal chemotropic factors, promote axon outgrowth, & control guidance of CNS commissural axons & peripheral motor axons
Structure:
- family of proteins homologous to C elegans UNC-6, a laminin related protein
Related
netrin receptor
Specific
netrin G1 (laminet-1, NTNG1, KIAA0976, LMNT1, UNQ571/PRO1133)
netrin G2 (laminet-2, NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206)
netrin-1 (NTN1, NTN1L)
netrin-2
netrin-2-like protein (NTN2L, NTN3)
Netrin-4; beta-netrin; hepar-derived netrin-like protein (NTN4)
General
glycoprotein
secreted protein
Properties
COMPARTMENT: extracellular compartment
MOTIF: glycosylation site
References
- Serafini T et al
The netrins define a family of axon outgrowth-promoting proteins
homologous to C. elegans UNC-6.
Cell. 1994 Aug 12;78(3):409-24.
PMID: 8062384
- Kennedy TE et al.
Netrins are diffusible chemotropic factors for commissural
axons in the embryonic spinal cord.
Cell 78:425-35, 1994
PMID: 8062385