Nephronectin (preosteoblast EGF-like repeat protein with MAM domain, protein EGFL6-like, NPNT, EGFL6L, POEM, UNQ295/PRO334)

Function: - ligand of integrin alpha-8/beta-1 in kidney development - regulates with integrin alpha-8/beta-1 the expression of GDNF which is essential for kidney development - may also play a role in the development & function of various tissues, regulating cell adhesion, spreading & survival through the binding of several integrins Structure: - homodimer & homotrimer (putative) - MAM domain is required for localization at the cell surface (putative) - belongs to the nephronectin family - contains 5 EGF-like domains - contains 1 MAM domain Compartment: - secreted, extracellular space, extracellular matrix (putative) - trapped on the cell surface or in the extracellular matrix (putative) Alternative splicing: named isoforms=2 Expression: - expressed in kidney & lung > brain, pregnant uterus, placenta, thyroid gland & blood vessel - expressed in fetal kidney, cochlea, eye, heart & lung

Properties

SIZE: entity length = 565 aa MW = 62 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} EGF domain {52-87} MOTIF: cysteine residue {C56} MODIFICATION: cysteine residue {C69} cysteine residue {C60} MODIFICATION: cysteine residue {C75} cysteine residue {C69} MODIFICATION: cysteine residue {C56} cysteine residue {C75} MODIFICATION: cysteine residue {C60} cysteine residue {C77} MODIFICATION: cysteine residue {C86} cysteine residue {C86} MODIFICATION: cysteine residue {C77} EGF domain {89-128} MOTIF: cysteine residue {C93} MODIFICATION: cysteine residue {C104} cysteine residue {C100} MODIFICATION: cysteine residue {C113} cysteine residue {C104} MODIFICATION: cysteine residue {C93} cysteine residue {C113} MODIFICATION: cysteine residue {C100} cysteine residue {C115} MODIFICATION: cysteine residue {C127} cysteine residue {C127} MODIFICATION: cysteine residue {C115} EGF domain {132-168} EGF domain {169-213} MOTIF: cysteine residue {C173} MODIFICATION: cysteine residue {C186} cysteine residue {C180} MODIFICATION: cysteine residue {C195} cysteine residue {C186} MODIFICATION: cysteine residue {C173} cysteine residue {C195} MODIFICATION: cysteine residue {C180} cysteine residue {C197} MODIFICATION: cysteine residue {C212} cysteine residue {C212} MODIFICATION: cysteine residue {C197} EGF domain {214-254} MOTIF: cysteine residue {C218} MODIFICATION: cysteine residue {C231} cysteine residue {C225} MODIFICATION: cysteine residue {C240} cysteine residue {C231} MODIFICATION: cysteine residue {C218} cysteine residue {C240} MODIFICATION: cysteine residue {C225} cysteine residue {C242} MODIFICATION: cysteine residue {C253} cysteine residue {C253} MODIFICATION: cysteine residue {C242} proline-rich region SITE: 296-365 MOTIF: proline residue (SEVERAL) Integrin interaction {382-384} MAM domain {420-563} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1}

Database Correlations

UniProt Q6UXI9 PFAM correlations

References

UniProt :accession Q6UXI9