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neonatal infection
Etiology:
risk factors
- invasive group B streptococcal infection in a previous baby
- maternal group B streptococcal colonisation, bacteriuria, or infection in the current pregnancy
- premature rupture of membranes
- preterm birth following spontaneous labor (before 37 weeks' gestation)
- intrapartum fever higher than 38 C
- confirmed or suspected chorioamnionitis
- parenteral antibiotic treatment given to the woman for confirmed or suspected invasive bacterial infection within 24-hours of birth, exlcuding intrapartum antibiotic prophylaxis
- suspected or confirmed infection in another baby in the case of a multiple pregnancy
Clinical manifestations:
- altered behaviour or responsiveness
- encephalopathy
- seizures
- altered muscle tone (for example, floppiness)
- feeding difficulties or intolerance
- refusal, vomiting, gastric retention, abdominal distension
- bradycardia or tachycardia
- respiratory distress
- apnea
- hypoxia
- need for cardiopulmonary resuscitation
- need for mechanical ventilation
- jaundice within 24 hours of birth
- persistent fetal circulation (persistent pulmonary hypertension)
- temperature abnormality (< 36 C or > 38 C)
- shock
- excessive bleeding, thrombocytopenia, or coagulation disorder (INR > 2.0)
- oliguria persisting beyond 24 hours after birth
- hypoglycemia or hyperglycemia
- metabolic acidosis (base deficit of 10 mmol/litre or greater)
- local signs of infection (i.e. skin or eye)
Specific
neonatal sepsis
General
infection (infectious disease)
neonatal disorder or disease