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N-ethylmaleimide [NEM]-sensitive fusion protein; vesicle-fusing ATPase; vesicular-fusion protein NSF (NSF)
Function:
- role in membrane fusion & vesicle trafficking
- required for vesicle-mediated transport
- catalyzes fusion of transport vesicles within the Golgi cisternae
- also required for transport from the endoplasmic reticulum to the Golgi stack
- seems to function as a fusion protein required for delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin
- interacts with GABARAP & GABARAPL2
Cofactor: binds 1 Mg+2 per subunit (putative)
Structure:
- homohexamer
- belongs to the AAA ATPase family
- homolog of yeast SEC18 product
Compartment: cytoplasm
Interactions
molecular events
Related
soluble NSF attachment protein (SNAP)
General
adenosine triphosphatase (ATPase)
fusion protein
oligomerizing protein
Properties
SIZE: entity length = 744 aa
MW = 83 kD
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y259}
ATP-binding site
NAME: ATP-binding site
SITE: 260-267
ATP-binding site
NAME: ATP-binding site
SITE: 543-550
MOTIF: Mg+2-binding site
SITE: 550-550
Database Correlations
OMIM 601633
UniProt P46459
PFAM correlations
Kegg hsa:4905
ENZYME 3.6.4.6
References
- Sollner T, Whiteheart SW, Brunner M et al
SNAP receptors implicated in vesicle targeting and fusion.
Nature. 1993 Mar 25;362(6418):318-24.
PMID: 8455717
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
- UniProt :accession P46459
Component-of
molecular complex