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negative elongation factor (NELF)
Function:
- cooperates with DSIF to repress RNA pol II elongation
- interacts with ARAF1
Structure:
- subunits: NELF-A, NELF-B, NELF-C/D, NELF-E
Related
protein synthesis elongation
General
molecular complex
translation elongation factor
Properties
COMPARTMENT: cytoplasm
CELL: most cell types*
ORGANISM: eukaryote*
SUBUNITS: negative elongation factor A
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T178}
HDAg-like {210-269}
MOTIF: Ser phosphorylation site {S254}
Thr phosphorylation site {T386}
negative elongation factor B
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S557}
negative elongation factor C/D
COMPARTMENT: cell nucleus
RD protein
References
Yamaguchi et al. Cell 97:41-51, 1999
Components
negative elongation factor A (NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein, WHSC2, P/OKcl.15)
negative elongation factor B (NELF-B, cofactor of BRCA1, NELFB, COBRA1, KIAA1182)
negative elongation factor C/D; NELF-C/D; TH1-like protein (NELFCD, TH1L, HSPC130)