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NEDD4-binding protein 1; N4BP1 (N4BP1 KIAA0615)
Function:
- inhibitor of the E3 ubiquitin-protein ligase ITCH
- acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates & impairing ubiquitination of substrates (putative)
- monoubiquitinated by NEDD4
- polyubiquitinated, leading to its degradation by the proteasome
- sumoylated by SUMO1, abrogating polyubiquitination & subsequent degradation
- desumoylated by SENP1, leading to accumulation in PML nuclear bodies
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with NEDD4
- interacts with ITCH (via WW domain 2) (putative)
Structure: belongs to the N4BP1 family
Compartment:
- nucleus, nucleolus, PML body (putative)
- primarily localizes to the nucleolus
- also localizes to the PML nuclear bodies, when desumoylated (putative)
Expression:
- detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis & ovary
Related
E3 ubiquitin-protein ligase NEDD4; cell proliferation-inducing gene 53 protein; neural cell expressed developmentally down-regulated protein 4; NEDD-4 (NEDD4, KIAA0093, NEDD4-1, PIG53)
General
Nedd4-binding protein
nuclear protein
Properties
SIZE: entity length = 896 aa
MW = 100 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S150}
Ser phosphorylation site {S226}
Thr phosphorylation site {T242}
Ser phosphorylation site {S258}
Database Correlations
UniProt O75113
Pfam PF11977
Entrez Gene 9683
Kegg hsa:9683
References
UniProt :accession O75113