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Nebulette; actin-binding Z-disk protein (NEBL)
Function:
- binds to actin & plays an important role in assembly of the Z-disk
Structure:
- contains 23 nebulin repeats
- contains 1 SH3 domain
Expression:
- abundantly expressed in cardiac muscle
- not expressed in skeletal or smooth muscle
- localized to Z-lines in cardiac cells & to dense bodies in nonmuscle cells
General
cytoskeletal protein
Properties
SIZE: MW = 116 kD
entity length = 1014 aa
COMPARTMENT: cytoplasm
MOTIF: NEBULIN {32-835} (23)
src homology 3 [SH3] domain
SITE: 954-1014
Database Correlations
OMIM 605491
UniProt O76041
PFAM correlations
Entrez Gene 10529
References
UniProt :accession O76041