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natural resistance-associated macrophage protein (Nramp)
Function:
- macrophage-specific membrane transport protein required for early lysis of intracellular pathogens by a mechanism distinct from that of activated macrophages
Expression:
- expressed in macrophages
Related
Nramp gene
Specific
natural resistance-associated macrophage protein 1 (NRAMP1, solute carrier family 11 member 1, SLC11A1, proton-coupled divalent metal ion transporter, LSH)
natural resistance-associated macrophage protein 2 (NRAMP2, divalent metal transporter 1, DMT1, solute carrier family 11 member 2, SLC11A2, OK/SW-cl20)
General
carrier protein (transporter)
glycoprotein
transmembrane 12 protein
Properties
COMPARTMENT: plasma membrane
CELL: macrophage
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
glycosylation site
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain {TM8}
transmembrane domain {TM9}
transmembrane domain {TM10}
transmembrane domain {TM11}
transmembrane domain {TM12}
cytoplasmic domain {C-TERMINAL}
References
Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 952