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natural killer cells antigen CD94; NK cell receptor; Killer cell lectin-like receptor subfamily D member 1; KP43; CD94 (KLRD1, CD94)
Function:
- plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- can form disulfide-bonded heterodimer with NKG2 family members
Structure: contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- natural killer cells
- gamma/delta T cells
- alpha/beta T cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family
killer cell lectin like receptor
Properties
SIZE: entity length = 179 aa
MW = 20 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {11-31}
cysteine residue {C61}
MODIFICATION: cysteine residue {C72}
cysteine residue {C72}
MODIFICATION: cysteine residue {C61}
N-glycosylation site {N83}
cysteine residue {C89}
MODIFICATION: cysteine residue {C174}
C-type lectin {98-176}
MOTIF: N-glycosylation site {N132}
cysteine residue {C152}
MODIFICATION: cysteine residue {C166}
cysteine residue {C166}
MODIFICATION: cysteine residue {C152}
cysteine residue {C174}
MODIFICATION: cysteine residue {C89}
Database Correlations
OMIM 602894
UniProt Q13241
Pfam PF00059
Entrez Gene 3824
Kegg hsa:3824
References
- UniProt :accession Q13241
- Functional Glycomics gateway - Glycan binding; Note: CD94
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_238