Search
nattokinase
- Nattokinase is an enzyme that comes from a Japanese food called natto [1]
- Natto is made from boiled soybeans fermented with bacterium Bacillus subtilis [1,2]
Uses:
- prevention & treatment of cardiovascular disease
* no good scientific evidence to support these uses [1]
Contraindications:
- patients with coagulation disorders
- patients undergoing anticoagulant, fibrinolytic, or antithrombotic treatment [3]
Dosage:
Capsule: 100 mg
Mechanism of action:
- cleaving & inactivating the plasminogen activator inhibitor (PAI) [3]
- in the absence of PAI, nattokinase affects direct proteolysis of fibrin
- fibrinolytic activity of nattokinase is ~4-fold that of plasmin
- potential as an amyloid plaque-degrading agent
- low doses of nattokinase increase expression of ADAM10, which belongs to a family of proteinases that degrade the amyloid precursor protein [3]
General
pharmaceutical herb; medicinal herb; herbal supplement; botanical
kinase or ATP-phosphotransferase
fibrinolytic agent (thrombolytic agent)
References
- WebMD
Nattokinase - Uses, Side Effects, and More
https://www.webmd.com/vitamins/ai/ingredientmono-1084/nattokinase
- Weng Y, Yao J, Sparks S, Wang KY.
Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease.
Int J Mol Sci. 2017 Feb 28;18(3):523.
PMID: 28264497 PMCID: PMC5372539 Free PMC article. Review.
- Memorial Sloan Kettering Cancer Center
Nattokinase. Purported Benefits, Side Effects & More
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/nattokinase