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natriuretic peptides A; CDD-ANF; prepronatriodilatin; contains: cardiodilatin-related peptide; CDP; contains: atrial natriuretic factor; ANF; atrial natriuretic peptide; ANP (NPPA, PND)
Function:
- hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, & vasodilation
- also plays a role in female pregnancy by promoting trophoblast invasion & spiral artery remodeling in uterus
- specifically binds & stimulates the cGMP production of the NPR1 receptor
- binds the clearance receptor NPR3
- cleaved by CORIN upon secretion to produce the functional hormone
Structure: belongs to the natriuretic peptide family
Compartment: secreted
Polymorphism:
- there are two different prepronatriodilatin alleles
- one codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide
Pathology:
- defects in NPPA are the cause of familial atrial fibrillation type 6
Specific
atrial natriuretic factor/peptide (ANF, ANP)
General
secreted protein
Properties
SIZE: entity length = 153 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
proteolytic site {123-124}
cysteine residue {C130}
MODIFICATION: cysteine residue {C146}
cysteine residue {C146}
MODIFICATION: cysteine residue {C130}
Database Correlations
OMIM correlations
UniProt P01160
Pfam PF00212
Entrez Gene 4878
Kegg hsa:4878
References
- UniProt :accession P01160
- Wikipedia; Note: atrial natriuretic peptide entry
http://en.wikipedia.org/wiki/atrial_natriuretic_peptide