nascent polypeptide-associated complex subunit alpha (NAC-alpha, alpha-NAC, Hom s 2.02, NACA)

Function: 1) component of nascent polypeptide-associated complex 2) may act as a specific coactivator for JUN, binding to DNA & stabilizing interaction of JUN homodimers with target gene promoters 3) interacts with TBP & JUN 4) phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization 5) phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation Structure: 1) belongs to the NAC-alpha family 2) contains 1 NAC-A/B domain (NAC-alpha/beta domain) - contains 1 UBA domain Compartment: cytoplasm, nucleus, predominantly cytoplasmic Pathology: - allergen; causes an allergic reaction in human - binds to IgE in patients with atopic dermatitis - identified as an IgE autoantigen in patients with atopic dermatitis with severe skin manifestations

General

DNA-binding protein phosphoprotein protein subunit

Properties

SIZE: MW = 23 kD entity length = 215 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S43} DNA-binding motif SITE: 69-80 NAC-A/B {70-135} Thr phosphorylation site {T159} Thr phosphorylation site {T161} Ser phosphorylation site {S166} UBA domain {176-213}

Database Correlations

OMIM 601234 UniProt Q13765 Pfam PF01849 Kegg hsa:4666

References

UniProt :accession Q13765