napsin-A; aspartyl protease 4; ASP4; Asp 4; napsin-1; TA01/TA02 (NAPSA, NAP1, NAPA)

Function: - may be involved in processing of pneumocyte surfactant precursors Structure: belongs to the peptidase A1 family Compartment: secreted (putative) Expression: - expressed predominantly in adult lung (type II pneumocytes) & kidney & in fetal lung - low expression in adult spleen - very low expression in peripheral blood leukocytes

General

aspartic proteinase; carboxyl acid protease glycoprotein secreted protein

Properties

SIZE: entity length = 420 aa MW = 45 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-25} N-glycosylation site {N90} aspartate residue {D96} cysteine residue {C109} MODIFICATION: cysteine residue {C116} cysteine residue {C116} MODIFICATION: cysteine residue {C109} N-glycosylation site {N133} cysteine residue {C274} MODIFICATION: cysteine residue {C278} cysteine residue {C278} MODIFICATION: cysteine residue {C274} aspartate residue {D283} cysteine residue {C317} MODIFICATION: cysteine residue {C354} N-glycosylation site {N336} cysteine residue {C354} MODIFICATION: cysteine residue {C317}

Database Correlations

OMIM 605631 UniProt O96009 Pfam PF00026 Entrez Gene 9476 Kegg hsa:9476