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nanoparticle RNA vaccine
Principle:
- nanoparticles containing RNA that encoding specific pathogen proteins
- an RNA replicon contains a start signal, coding region a protein & a stop signal
- once inside a cell, the replican can produce protein
- vaccine against a specific microbe can be created in 1 week
Comparative biology:
- mice provided a single dose nanoparticle RNA vaccine for H1N1 influenza, Toxoplasma gondii, or Ebolavirus sustained protection against lethal doses of each of these pathogens
- no evidence of an immune response against the nanoparticle
General
vaccine
References
- Chahal JS, Khan OF, Cooper CL et al.
Dendrimer-RNA nanoparticles generate protective immunity
against lethal Ebola, H1N1 influenza, and Toxoplasma gondii
challenges with a single dose.
Proc Natl Acad Sci U S A 2016 Jul 19; 113:E4133.
PMID: 27382155