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neuronal apoptosis inhibitory (NAIP) gene

Pathology: - gene for NAIP is linked to a recessive childhood spinal muscular atrophy Genetics: - NAIP gene shows lineage-specific gene duplication in the human genome relative to chimpanzee & other great apes [3]

Related

baculoviral IAP repeat-containing protein 1; neuronal apoptosis inhibitory protein (NAIP, BIRC1) childhood spinal muscular atrophy

General

evolutionary divergent human gene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: baculoviral IAP repeat-containing protein 1 LOCUS: human chromosome-5 Q13 SIZE: entity length = 70 KB MOTIF: transcription factor binding site transcriptional start site exon (16) intron (15) transcriptional termination site

References

  1. Roy et al. Cell 80:167-78 1995
  2. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science. 1995 Mar 10;267(5203):1456-62. Review. PMID: 7878464
  3. Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour- Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13. PMID: 15252450