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NAD isocitrate dehydrogenase

Function: - activated by increasing ADP/ATP ratios & by Ca+2 (putative) isocitrate + NAD+ 2-oxoglutarate + CO2 + NADH Structure: - heterooligomer of subunits IDH3A (alpha), IDH3B (beta), & IDH3G (gamma) in the apparent ratio of 2:1:1

General

citric acid cycle enzyme isocitrate dehydrogenase multisubunit protein

Properties

COMPARTMENT: mitochondrial matrix MOTIF: active site SUBUNITS: NAD isocitrate dehydrogenase alpha subunit (2) MOTIF: binding site SITE: 115-115 FOR-BINDING-OF: Substrate binding site SITE: 125-125 FOR-BINDING-OF: Substrate binding site SITE: 146-146 FOR-BINDING-OF: Substrate tyrosine residue {153} lysine residue {200} manganese [Mn]-binding site SITE: 233-233 MOTIF: binding site SITE: 233-233 FOR-BINDING-OF: Substrate manganese [Mn]-binding site SITE: 257-257 manganese [Mn]-binding site SITE: 261-261 NAD isocitrate dehydrogenase beta subunit MOTIF: binding site SITE: 133-133 FOR-BINDING-OF: Substrate binding site SITE: 164-164 FOR-BINDING-OF: Substrate tyrosine residue {171} lysine residue {218} manganese [Mn]-binding site SITE: 251-251 MOTIF: binding site SITE: 251-251 FOR-BINDING-OF: Substrate NAD isocitrate dehydrogenase gamma subunit MOTIF: binding site SITE: 136-136 FOR-BINDING-OF: Substrate binding site SITE: 167-167 FOR-BINDING-OF: Substrate tyrosine residue {174} lysine residue {221} manganese [Mn]-binding site SITE: 254-254 MOTIF: binding site SITE: 254-254 FOR-BINDING-OF: Substrate ATP-binding site NAME: ATP-binding site SITE: 309-316 Thr phosphorylation site {T363}

Database Correlations

OMIM 147650 ENZYME 1.1.1.41

References

  1. UniProt :accession P50213
  2. UniProt :accession O43837
  3. UniProt :accession P51553

Components

NAD isocitrate dehydrogenase alpha subunit (IDH3A) NAD isocitrate dehydrogenase beta subunit (IDH3B) NAD isocitrate dehydrogenase gamma subunit (IDH3G)