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NADPH oxidase 3; mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3 (NOX3, MOX2)
Function:
1) NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox
2) biogenesis of otoconia
3) activated by the ototoxic drug cisplatin
4) activated by NOXO1
5) cooperatively activated by NCF1 & NCF2 or NOXA1 phorbol ester dependent
6) contains 1 ferric oxidoreductase domain, residues 55-549
Inhibition:
- inhibited by diphenyleneiodonium chloride
Structure:
- contains 1 FAD-binding FR-type domain
- contains 1 ferric oxidoreductase domain
Compartment: membrane (putative)
Expression:
- expressed in fetal kidney > liver, lung & spleen
Related
NADPH oxidase
General
glycoprotein
oxidoreductase
transmembrane 6 protein
Properties
SIZE: MW = 65 kD
entity length = 568 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-13}
transmembrane domain {14-34}
exoplasmic loop {35-51}
transmembrane domain {52-72}
cytoplasmic loop {73-103}
transmembrane domain {104-124}
exoplasmic loop {125-167}
MOTIF: N-glycosylation site {N163}
transmembrane domain {168-188}
cytoplasmic loop {189-201}
transmembrane domain {202-222}
exoplasmic loop {223-395}
MOTIF: N-glycosylation site {N238}
transmembrane domain {396-416}
cytoplasmic domain {417-568}
Database Correlations
OMIM 607105
UniProt Q9HBY0
PFAM correlations
Entrez Gene 50508
Kegg hsa:50508
References
UniProt :accession Q9HBY0