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NAD (nicotinamide adenine dinucleotide)
Indications:
- proposed as anti-aging substance [1]
Mechanism of action:
- product of nicotinamide phosphoribosyltransferase
- activates SIRT1 activity [1]
- increases capillary density & blood flow in skeletal muscle of old mice via activation of SIRT1
- NAD-booster NMN mimics & augments exercise by inhibiting NICD-NOTCH (in mice) [2]
- increases endurance in old mice [2]
Interactions
molecular events
Related
citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
electron transport
nicotinamide (a vitamin B3, NMN)
nicotinamide mononucleotide
General
cofactor
intermediary metabolite
nicotinate ribonucleotide
purine nucleotide
Properties
Database Correlations
PUBCHEM correlations
References
- Imai S
A possibility of nutriceuticals as an anti-aging intervention:
activation of sirtuins by promoting mammalian NAD biosynthesis.
Pharmacol Res. 2010 Jul;62(1):42-7
PMID: 20085812 Free PMC Article
- Das A, Huang GX, Bonkowski MS et al.
Impairment of an endothelial NAD+ -H2S signaling network
is a reversible cause of vascular aging.
Cell 2018 Mar 22; 173:74-89
PMID: 29570999
- Rajman L, Chwalek K, Sinclair DA.
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo
Evidence.
Cell Metab. 2018 Mar 6;27(3):529-547. Review.
PMID: 29514064
Substructures
adenosine (Adenocard, Adenoscan)
nicotinamide (a vitamin B3, NMN)
Component-of
biotin/nad/panthenol/zinc pyrithione