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Na+/K+/Ca+2 exchanger 4; Na+/K+/Ca+2-exchange protein 4; solute carrier family 24 member 4 (SLC24A4, NCKX4)
Function:
- transports 1 Ca+2 & 1 K+ in exchange for 4 Na+
Structure:
- belongs to the Na+/K+/Ca+2 exchanger family, SLC24A subfamily
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- expressed abundantly in all regions of the brain, aorta, lung & thymus
- expressed at lower levels in the stomach & intestine
Polymorphism:
- genetic variations in SLC24A4 are associated with skin/hair/eye pigmentation type 6
Note: uncertain whether Met-1 or Met-18 is the initiator
General
glycoprotein
Na+/K+/Ca+2 antiporter or exchanger
solute carrier family 24 (SLC24, SLC24A)
transmembrane 10e protein
Properties
SIZE: MW = 67 kD
entity length = 605 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-80}
MOTIF: signal sequence {1-21}
N-glycosylation site {N52}
N-glycosylation site {N59}
transmembrane domain {81-101}
cytoplasmic loop {102-155}
transmembrane domain {156-176}
exoplasmic loop {177-183}
transmembrane domain {184-204}
cytoplasmic loop {205-207}
transmembrane domain {208-228}
exoplasmic loop {229-407}
MOTIF: proline residue {378-389} (12)
transmembrane domain {408-428}
cytoplasmic loop {429-440}
transmembrane domain {441-461}
exoplasmic loop {462-462}
transmembrane domain {463-483}
cytoplasmic loop {484-509}
transmembrane domain {510-530}
exoplasmic loop {531-540}
transmembrane domain {541-561}
cytoplasmic loop {562-569}
transmembrane domain {570-590}
exoplasmic domain {591-605}
Database Correlations
OMIM correlations
UniProt Q8NFF2
Pfam PF01699
Entrez Gene 123041
Kegg hsa:123041
References
UniProt :accession Q8NFF2