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Na+/K+/Ca+2 exchanger 2; Na+/K+/Ca(2+)-exchange protein 2; retinal cone Na-Ca+K exchanger; solute carrier family 24 member 2 (SLC24A2 NCKX2)
Function:
- component of the visual transduction cascade
- controls Ca+2 concentration of outer segments during light & darkness
- light causes a rapid lowering of cytosolic free Ca+2 in the outer segment of both retinal rod & cone photoreceptors
- the light-induced lowering of Ca+2 is caused by extrusion of Ca+2 via SLC24A2, thus its role in light adaptation
- transports 1 Ca+2 & 1 K+ in exchange for 4 Na+
Structure:
- belongs to the Na+/K+/Ca+2 exchanger family, SLC24A subfamily
Compartment: membrane
Alternative splicing: named isoforms=2
General
glycoprotein
Na+/K+/Ca+2 antiporter or exchanger
solute carrier family 24 (SLC24, SLC24A)
transmembrane 11 protein
Properties
SIZE: entity length = 661 aa
MW = 74 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-38}
transmembrane domain {39-59}
exoplasmic loop {60-132}
MOTIF: N-glycosylation site {N111}
transmembrane domain {133-153}
cytoplasmic loop {154-178}
transmembrane domain {179-199}
exoplasmic loop {200-204}
transmembrane domain {205-225}
cytoplasmic loop {226-243}
transmembrane domain {244-264}
exoplasmic loop {265-265}
transmembrane domain {266-286}
cytoplasmic loop {287-497}
transmembrane domain {498-518}
exoplasmic loop {519-533}
transmembrane domain {534-554}
cytoplasmic loop {555-569}
transmembrane domain {570-590}
exoplasmic loop {591-602}
transmembrane domain {603-623}
cytoplasmic loop {624-630}
transmembrane domain {631-651}
exoplasmic domain {652-661}
Database Correlations
OMIM 609838
UniProt Q9UI40
Pfam PF01699
Entrez Gene 25769
Kegg hsa:25769
References
UniProt :accession Q9UI40