Na+/H+ exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Na+-hydrogen exchanger regulatory factor 2; solute carrier family 9 isoform A3 regulatory factor 2; tyrosine kinase activator protein 1; TKA-1 (SLC9A3R2, NHERF2)

Function: - scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family & thereby helps to link them to the actin cytoskeleton & to regulate their surface expression - necessary for cAMP-mediated phosphorylation & inhibition of SLC9A3 - may also act as scaffold protein in the nucleus - homodimer, & heterodimer with SLC9A3R1 - binds PDZK1 - found in a complex with EZR, PODXL & SLC9A3R2 (putative) - interacts (via the PDZ domains) with PODXL (via C-terminal PDZ-binding motif DTHL); interaction is detected in glomerular epithelium cells (putative) - binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX & LPAR2 - interacts with MCC & PODXL Structure: - contains 2 PDZ domain (DHR domain)s Compartment: - endomembrane system, peripheral membrane - nucleus. apical cell membrane (putative) - localizes with EZR & PODXL at the apical cell membrane of glomerular epithelium cells & their foot processes (putative) - nuclear, in a punctate pattern Alternative splicing: named isoforms=2 Expression: widely expressed

General

nuclear protein phosphoprotein scaffold protein

Properties

SIZE: entity length = 337 aa MW = 37 kD COMPARTMENT: cell nucleus MOTIF: PDZ domain NAME: PDZ domain SITE: 11-90 PDZ domain NAME: PDZ domain SITE: 150-230 MOTIF: Ser phosphorylation site {S183} Ser phosphorylation site {S254} Ser phosphorylation site {S272} Ser phosphorylation site {S275}

Database Correlations

OMIM 606553 UniProt Q15599 PFAM correlations Entrez Gene 9351 Kegg hsa:9351

References

UniProt :accession Q15599