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solute carrier family 23 member 1; Na+ dependent vitamin C transporter 1; hSVCT1; Na+/L-ascorbic acid transporter 1; yolk sac permease-like molecule 3 (SLC23A1, SVCT1, YSPL3)
Function:
- Na+/ascorbate cotransporter. mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate
- phosphorylated (probable)
Structure:
- belongs to the xanthine/uracil permease family, SLC23A subfamily
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate & liver, & in fetal kidney, liver & thymus
- treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells
General
glycoprotein
solute carrier family 23 (SLC23, SLC23A)
symporter
Properties
SIZE: MW = 65 kD
entity length = 598 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {53-73}
transmembrane domain {82-102}
transmembrane domain {104-124}
N-glycosylation site {N138}
N-glycosylation site {N144}
cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
transmembrane domain {160-180}
transmembrane domain {208-228}
N-glycosylation site {N230}
transmembrane domain {251-271}
transmembrane domain {313-333}
transmembrane domain {359-379}
transmembrane domain {403-423}
transmembrane domain {427-447}
cytoplasmic domain {C-TERMINAL}
transmembrane domain {458-478}
transmembrane domain {491-511}
Database Correlations
OMIM 603790
UniProt Q9UHI7
Pfam PF00860
Kegg hsa:9963
References
UniProt :accession Q9UHI7