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Na+-dependent phosphate transporter 2 (solute carrier family 20 member 2, phosphate transporter 2, PiT-2, pit2, Gibbon ape leukemia virus receptor 2, GLVR-2, SLC20A2, GLVR2, PIT2)
Function:
- Na+-phosphate symporter
- seems to play a housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, & nucleic acid & lipid synthesis
- in vitro, Na+-dependent phosphate uptake is not siginificantly affected by acidic & alkaline conditions; however, Na+-independent phosphate uptake occurs at acidic conditions
- may play a role in extracellular matrix, cartilage & vascular calcification
Structure:
- homodimer
- belongs to the pho-4 transporter (TC 2.A.20.-) family
Compartment: cell membrane; multi-pass membrane protein
Expression:
- ubiquitously expressed
- expression increased by phosphate depletion in osteosarcoma cell lines
Pathology:
- functions as a retroviral receptor & confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) & some feline leukemia virus subgroup B (FeLV-B) variants
General
glycoprotein
receptor
solute carrier family 20 (SLC20, SLC20A)
transmembrane 12e protein
Properties
SIZE: entity length = 652 aa
MW = 70 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-5}
transmembrane domain {6-26}
cytoplasmic loop {27-46}
transmembrane domain {47-67}
exoplasmic loop {68-86}
MOTIF: N-glycosylation site {N81}
transmembrane domain {87-107}
cytoplasmic loop {108-109}
transmembrane domain {110-130}
exoplasmic loop {131-142}
transmembrane domain {143-163}
cytoplasmic loop {164-190}
transmembrane domain {191-211}
exoplasmic loop {212-213}
transmembrane domain {214-234}
cytoplasmic loop {235-482}
transmembrane domain {483-503}
exoplasmic loop {504-530}
transmembrane domain {531-551}
cytoplasmic loop {552-571}
transmembrane domain {572-586}
exoplasmic loop {587-593}
transmembrane domain {594-609}
cytoplasmic loop {610-621}
transmembrane domain {622-642}
exoplasmic domain {643-652}
Database Correlations
OMIM 158378
UniProt Q08357
Pfam PF01384
Kegg hsa:6575
References
UniProt :accession Q08357