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Na+-coupled neutral amino acid transporter 5 (system N transporter 2, solute carrier family 38 member 5, SLC38A5, JM24, SN2, SNAT5, PP7194)
Function:
- Na+-dependent amino acid transporter which countertransport protons
- mediates the saturable, pH-sensitive, & electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine & histidine with Na+
- not inhibited by Li+
Kinetic parameters: KM=0.6 mM for histidine (at pH 8.0)
Structure:
- belongs to the amino acid/polyamine transporter 2 family
Compartment: cell membrane; Multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression:
- predominantly expressed in stomach, brain, liver, lung & intestinal tract
Pathology:
- chromosomal aberration involving SLC38A5 is found in 3 brothers with non-syndromic mental retardation
- homozygous interstitial microdeletion at Xp11.23 causes also loss of FTSJ1 & the link between SLC38A5 & the disease is not clear
General
glycoprotein
solute carrier family 38 (SLC38, SLC38A)
transmembrane 11 protein
Properties
SIZE: entity length = 472 aa
MW = 51 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-48}
transmembrane domain {49-71}
exoplasmic loop {72-87}
transmembrane domain {88-108}
cytoplasmic loop {109-125}
transmembrane domain {126-146}
exoplasmic loop {147-166}
transmembrane domain {167-187}
cytoplasmic loop {188-192}
transmembrane domain {193-213}
exoplasmic loop {214-257}
MOTIF: N-glycosylation site {N226}
transmembrane domain {258-278}
cytoplasmic loop {279-295}
transmembrane domain {296-316}
exoplasmic loop {317-334}
transmembrane domain {335-355}
cytoplasmic loop {356-376}
transmembrane domain {377-397}
exoplasmic loop {398-399}
transmembrane domain {400-420}
cytoplasmic loop {421-439}
transmembrane domain {440-460}
exoplasmic domain {461-472}
Database Correlations
UniProt Q8WUX1
Pfam PF01490
References
UniProt :accession Q8WUX1