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Na+-coupled neutral amino acid transporter 4 (amino acid transporter A3, system A amino acid transporter 3, system N amino acid transporter 3, solute carrier family 38 member 4, SLC38A4, ATA3, NAT3, SNAT4)
Function:
1) Na+-dependent amino acid transporte
2) mediates electrogenic symport of neutral amino acids & Na+
3) broad specificity, with a preference for Ala > His, Cys, Asn, Ser, Gly, Val, Thr, Gln & Met
4) may mediate Na+-independent transport of cationic amino acids, Arg & Lys
5) amino acid uptake is pH-dependent, pH optimum 7.5-8.5
Structure:
- belongs to the amino acid/polyamine transporter 2 family
Compartment: cell membrane
Expression:
- expressed in embryonic & adult liver > adult muscle, kidney, pancreas
- expressed in placenta syncytiotrophoblasts throughout gestation
- expressed in fetal blood vessels
General
amino acid transport protein
glycoprotein
solute carrier family 38 (SLC38, SLC38A)
transmembrane 11 protein
Properties
SIZE: MW = 61 kD
entity length = 547 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-80}
transmembrane domain {81-101}
exoplasmic loop {102-104}
transmembrane domain {105-125}
cytoplasmic loop {126-151}
transmembrane domain {152-172}
exoplasmic loop {173-195}
transmembrane domain {196-216}
cytoplasmic loop {217-220}
transmembrane domain {221-241}
exoplasmic loop {242-332}
MOTIF: N-glycosylation site {N260}
N-glycosylation site {N264}
N-glycosylation site {N276}
transmembrane domain {333-353}
cytoplasmic loop {354-369}
transmembrane domain {370-390}
exoplasmic loop {391-411}
transmembrane domain {412-432}
cytoplasmic loop {433-453}
transmembrane domain {454-474}
exoplasmic loop {475-476}
transmembrane domain {477-497}
cytoplasmic loop {498-514}
transmembrane domain {515-535}
exoplasmic domain {536-547}
Database Correlations
OMIM 608065
UniProt Q969I6
Pfam PF01490
References
UniProt :accession Q969I6