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Na+/Cl- dependent glycine transporter 1; GlyT1; solute carrier family 6 member 9 (SLC6A9)
Function:
- terminates action of glycine by high affinity Na+ dependent reuptake of glycine into presynaptic terminals
- may play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission
Structure:
- belongs to the Na+:neurotransmitter symporter (SNF) family
Compartment: membrane
Alternative splicing: named isoforms=3, GlyT-1A, 1B, 1C
Expression:
- all GLYT-1 subtypes can be found in brain, kidney, pancreas, lung, placenta, liver
- GLYT-1C subtype is only found in the brain
General
amino acid transport protein
glycoprotein
solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)
Properties
SIZE: MW = 77 kD
entity length = 692 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-94}
transmembrane domain {95-115}
exoplasmic loop {116-122}
transmembrane domain {123-142}
cytoplasmic loop {143-165}
transmembrane domain {166-186}
exoplasmic loop {187-273}
MOTIF: N-glycosylation site {N223}
N-glycosylation site {N226}
N-glycosylation site {N236}
N-glycosylation site {N242}
transmembrane domain {274-292}
cytoplasmic loop {293-300}
transmembrane domain {301-318}
exoplasmic loop {319-353}
transmembrane domain {354-371}
cytoplasmic loop {372-382}
transmembrane domain {383-404}
exoplasmic loop {405-436}
transmembrane domain {437-456}
cytoplasmic loop {457-484}
transmembrane domain {485-503}
exoplasmic loop {504-518}
transmembrane domain {519-539}
cytoplasmic loop {540-559}
transmembrane domain {560-579}
exoplasmic loop {580-597}
transmembrane domain {598-616}
cytoplasmic domain {618-692}
Database Correlations
OMIM 601019
UniProt P48067
Pfam PF00209
Entrez Gene 6536
Kegg hsa:6536
References
UniProt :accession P48067