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Na+/Cl- dependent GABA transporter 2; solute carrier family 6 member 13 (SLC6A13)
Function:
- Na+-dependent GABA & taurine transporter
- terminates action of GABA with high affinity
- Na+ dependent reuptake of GABA into presynaptic terminals
- may also be involved in beta-alanine transport
Kinetic parameters:
- KM=3.7 uM for GABA
- KM=20.2 uM for beta-alanine
Structure:
- belongs to the Na+:neurotransmitter symporter (SNF) family
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, kidney, lung, liver & testis
Genetics:
- the SLC6A13 gene shows lineage-specific gene duplication in the human genome relative to chimpanzee & other great apes [2]
Related
SLC6A13 (Na+/Cl- dependent GABA transporter 2 ) gene
General
evolutionary divergent human protein
glycoprotein
solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)
Properties
SIZE: MW = 64 kD
entity length = 569 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-22}
transmembrane domain {23-43}
exoplasmic loop {44-50}
transmembrane domain {51-70}
cytoplasmic loop {71-94}
transmembrane domain {95-115}
exoplasmic loop {117-187}
MOTIF: N-glycosylation site {N151}
N-glycosylation site {N155}
N-glycosylation site {N160}
transmembrane domain {188-206}
cytoplasmic loop {207-214}
transmembrane domain {215-232}
exoplasmic loop {233-267}
transmembrane domain {268-285}
cytoplasmic loop {286-292}
transmembrane domain {293-308}
exoplasmic loop {309-340}
transmembrane domain {341-360}
cytoplasmic loop {342-389}
transmembrane domain {390-408}
exoplasmic loop {409-424}
transmembrane domain {425-445}
cytoplasmic loop {446-465}
transmembrane domain {466-485}
exoplasmic loop {486-504}
transmembrane domain {505-523}
cytoplasmic domain {524-569}
Database Correlations
UniProt Q9NSD5
Pfam PF00209
Entrez Gene 6540
Kegg hsa:6540
References
- UniProt :accession Q9NSD5
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L,
Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-
Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM.
Lineage-specific gene duplication and loss in human and great
ape evolution.
PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13.
PMID: 15252450
- PMID: 22932902
- PMID: 11824941
- PMID: 17502375