Search
Na+/K+/Ca+2 exchanger 6, mitochondrial; Na+/K+/Ca+2-exchange protein 6; Na+/Ca+2 exchanger protein, mitochondrial; solute carrier family 24 member 6; solute carrier family 8 member B1 (SLC8B1, NCKX6, NCLX, SLC24A6)
Function:
- mitochondrial Na+/Ca+2 antiporter
- mediates Ca+-dependent Ca+2 efflux from mitochondria
- regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion:
- acts by mediating efflux of Ca+2 from mitochondrion, thus affecting cytoplasmic Ca+2 responses
- transports Ca+2 in exchange for either Li+ or Na+
- in contrast to other members of the family, its function is independent of K+ Inhibitor: Zn+2
Structure:
- belongs to the sodium/potassium/calcium exchanger family, SLC24A subfamily.
Compartment:
- mitochondrial inner membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression:
- present in pancreatic beta-cells (at protein level)
General
glycoprotein
mitochondrial protein
solute carrier family 24 (SLC24, SLC24A)
solute carrier family 8 (SLC8, SLC8A, Na+/Ca+2 exchanger)
transmembrane 13 protein
Properties
SIZE: MW = 64 kD
entity length = 584 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-95}
MOTIF: signal sequence {1-26}
N-glycosylation site {N60}
transmembrane domain {96-116}
cytoplasmic loop {117-140}
transmembrane domain {141-161}
exoplasmic loop {162-168}
transmembrane domain {169-189}
cytoplasmic loop {190-200}
transmembrane domain {201-221}
exoplasmic loop {222-226}
transmembrane domain {227-247}
cytoplasmic loop {248-325}
transmembrane domain {326-346}
exoplasmic loop {347-360}
transmembrane domain {361-381}
cytoplasmic loop {382-383}
transmembrane domain {384-404}
exoplasmic loop {405-416}
transmembrane domain {417-437}
cytoplasmic loop {438-445}
transmembrane domain {446-466}
exoplasmic loop {467-487}
transmembrane domain {488-508}
cytoplasmic loop {509-524}
transmembrane domain {525-545}
exoplasmic loop {546-558}
transmembrane domain {559-579}
cytoplasmic domain {580-584}
Database Correlations
UniProt Q6J4K2
Pfam PF01699
References
UniProt :accession Q6J4K2