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Na+/hydrogen exchanger 10; Na+/H+ exchanger 10; sperm-specific Na+/H+ exchanger; sNHE; solute carrier family 9 member 10 (SLC9A10, SLC9C1)
Function:
- sperm-specific Na+/hydrogen exchanger
- involved in intracellular pH regulation of spermatozoa
- required for sperm motility & fertility
- involved in sperm cell hyperactivation, a step needed for sperm motility
- required for the expression & bicarbonate regulation of the soluble adenylyl cyclase (putative)
- interacts with soluble adenylyl cyclase
Structure:
- ion transport-like region is related to the membrane segments of voltage-gated ion channels
- belongs to the Na+/H+ exchanger (TC 2.A.36.5.1) family
- contains 1 cyclic nucleotide-binding domain
Compartment:
- cell projection, cilium, flagellum, membrane
Alternative splicing: named isoforms=2
General
glycoprotein
membrane protein
solute carrier family 9 (SLC9, SLC9A)
Properties
SIZE: entity length = 1177 aa
MW = 135 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {8-28}
transmembrane domain {39-59}
transmembrane domain {73-93}
transmembrane domain {103-123}
transmembrane domain {138-158}
transmembrane domain {167-187}
transmembrane domain {204-224}
transmembrane domain {248-268}
N-glycosylation site {N278}
transmembrane domain {301-321}
transmembrane domain {333-353}
transmembrane domain {364-384}
transmembrane domain {405-425}
Ion transport-like {598-678}
MOTIF: transmembrane domain {613-633}
transmembrane domain {646-666}
transmembrane domain {675-695}
transmembrane domain {707-727}
cyclic nucleotide-binding site
SITE: 870-1003
Database Correlations
UniProt Q4G0N8
PFAM correlations
References
UniProt :accession Q4G0N8