Na+/H+ exchanger NHE5 (solute carrier family 9 isoform A5, SLC9A5)

Function: - role in pH regulation to eliminate acids generated by active metabolism or adverse environmental conditions - major proton extruding system - driven by the inward Na⁺ chemical gradient - role in signal transduction (putative) - phosphorylated (possible) Structure: - belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family Compartment: membrane Expression: - expressed in brain, testis, spleen, & skeletal muscle

General

glycoprotein solute carrier family 9 (SLC9, SLC9A) transmembrane 12 protein

Properties

SIZE: MW = 99 kD entity length = 896 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {TM1} transmembrane domain {TM2} transmembrane domain {TM3} transmembrane domain {TM4} transmembrane domain {TM5} transmembrane domain {TM6} transmembrane domain {TM7} transmembrane domain {TM8} transmembrane domain {TM9} transmembrane domain {TM10} transmembrane domain {TM11} transmembrane domain {TM12} transmembrane domain {46-66} transmembrane domain {74-94} transmembrane domain {104-124} transmembrane domain {135-155} transmembrane domain {174-194} N-glycosylation site {N199} transmembrane domain {201-221} cytoplasmic domain {N-TERMINAL} exoplasmic loop LOOP#: 1 exoplasmic loop LOOP#: 2 exoplasmic loop LOOP#: 3 exoplasmic loop LOOP#: 4 exoplasmic loop LOOP#: 5 exoplasmic loop LOOP#: 6 transmembrane domain {247-267} transmembrane domain {277-297} N-glycosylation site {N319} transmembrane domain {332-352} transmembrane domain {361-381} transmembrane domain {399-419} transmembrane domain {429-449} cytoplasmic domain {C-TERMINAL}

Database Correlations

OMIM 600477 UniProt Q14940 Pfam PF00999 Entrez Gene 6553 Kegg hsa:6553