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M-phase phosphoprotein 8; Two hybrid-associated protein 3 with RanBPM; Twa3 (MPHOSPH8 MPP8)
Function:
- phosphorylated in M-phase
Structure:
- contains 4 ANK repeats
- contains 1 chromo domain
Compartment: nucleus
Alternative splicing: named isoforms=2
General
ankyrin repeat domain protein (ANKRD)
M-phase phosphoprotein
nuclear protein
Properties
SIZE: entity length = 860 aa
MW = 97 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S51}
chromodomain
NAME: chromodomain
SITE: 59-118
FOR-BINDING-OF: heterochromatin
Ser phosphorylation site {S136}
Ser phosphorylation site {S138}
Ser phosphorylation site {S149}
lysine-rich region {151-256}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S164}
Ser phosphorylation site {S188}
Ser phosphorylation site {S189}
Ser phosphorylation site {S192}
Ser phosphorylation site {S272}
Ser phosphorylation site {S319}
Thr phosphorylation site {T334}
Thr phosphorylation site {T385}
Ser phosphorylation site {S392}
Ser phosphorylation site {S403}
Thr phosphorylation site {T454}
ankyrin repeat
NAME: ankyrin repeat
SITE: 600-629
ankyrin repeat
NAME: ankyrin repeat
SITE: 633-662
ankyrin repeat
NAME: ankyrin repeat
SITE: 666-695
ankyrin repeat
NAME: ankyrin repeat
SITE: 699-728
Database Correlations
OMIM 611626
UniProt Q99549
PFAM correlations
Entrez Gene 54737
Kegg hsa:54737
References
UniProt :accession Q99549