M-phase phosphoprotein 1; MPP1; kinesin-related motor interacting with PIN1 (MPHOSPH1, KRMP1, KIF20B)

Function: - plus-end-directed motor enzyme required for completion of cytokinesis - interacts with PIN - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the kinesin-like protein family - contains 1 kinesin-motor domain Compartment: - cytoplasm, nucleus - localizes mainly in nucleus during interphase - during prophase & metaphase, found throughout cytoplasm - at anaphase, concentrated in the mid-body Alternative splicing: named isoforms=5 Expression: - expressed in brain, ovary, kidney, testis - 2-3 fold expression increase is seen as cells progress from G1 to G2/Mphase

General

cytoskeletal protein M-phase phosphoprotein

Properties

SIZE: MW = 211 kD entity length = 1820 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: kinesin motor domain SITE: 55-405 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 152-159 binding site FOR-BINDING-OF: microtubule Ser phosphorylation site {S303} Ser phosphorylation site {S488} coiled coil {523-603} coiled coil {674-793} Ser phosphorylation site {S999} glutamate-rich region {1247-1251} MOTIF: glutamate residue (SEVERAL) interaction with PIN1 {1560-1820} MOTIF: Thr phosphorylation site {T1644}

Database Correlations

OMIM 605498 UniProt Q96Q89 Pfam PF00225

References

UniProt :accession Q96Q89