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M-phase inducer phosphatase-3 (dual specificity phosphatase Cdc25C, CDC25C)

Function: - tyrosine protein phosphatase - dosage-dependent inducer in mitotic control - required forprogression of the cell cycle - directly dephosphorylates CDC2 & activates its kinase activity - interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity - phosphorylated by CHK1 on Ser-216, this creates a binding site for 14-3-3 protein & inhibits the phosphatase protein tyrosine phosphate + H2O protein tyrosine + phosphate Structure: - belongs to the MPI phosphatase family - contains 1 rhodanese domain Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - expressed predominantly in G2 phase

Interactions

molecular events

General

M-phase inducer phosphatase or CDC25

Properties

SIZE: entity length = 473 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S168} Ser phosphorylation site {S216} Rhodanese {321-428} MOTIF: HIV-1 Vpr binding site {334-379} cysteine residue {C377} STATE: active state

References

  1. UniProt :accession P30307

Component-of

molecular complex

Databases & Figures

OMIM 157680 UniProt P30307 Entrez Gene 995 ENZYME 3.1.3.48 Figures/diagrams/slides/tables related to M-phase inducer phosphatase-3