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M-phase inducer phosphatase-2 (dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2)
Function:
- tyrosine protein phosphatase
- dosage-dependent inducer of mitotic progression
- directly dephosphorylates CDC2 & stimulates its kinase activity
- the 3 isoforms seem to have a different level of activity
- stimulated by B-type cyclins
- phosphorylated by BRSK1 in vitro
- phosphorylated by CHEK1, which inhibits its activity
protein tyrosine phosphate + H2O protein tyrosine + phosphate
Structure:
- belongs to the MPI phosphatase family
- contains 1 rhodanese domain
Compartment: centrosome
Alternative splicing: named isoforms=4
General
M-phase inducer phosphatase or CDC25
Properties
SIZE: entity length = 580 aa
MW = 65 kD
COMPARTMENT: cell nucleus
CELL-CYCLE: G2
MOTIF: Rhodanese {431-538}
MOTIF: cysteine residue {C487}
STATE: active state
Database Correlations
OMIM 116949
UniProt P30305
Entrez Gene 994
ENZYME 3.1.3.48
References
- UniProt :accession P30305