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myricetin; cannabiscetin
Occurrence:
- derived from vegetables, fruits, oranges, nuts, berries, tea
- kale, beans, spinach, apples, olive oil, & tomato sauce
- also found in red wine
Mechanism of action:
- antioxidant
- pro-oxidant when interacting with DNA [1]
- may enhance DNA cleavage by topoisomerase II [2]
- anti-carcinogen
- mutagen in Ames Salmonella assay
- antiviral
- antithrombotic
- anti-diabetic
- may reduce atherosclerosis & cardiovascular risk
- neuroprotection
- may be one of dietary bioflavonoids that reduce risk of Alzheimer's disease [3]
- anti-inflammatory
- anti-aging?
Notes:
- average intake of myricetin per day varies depending on diet
- in the Netherlands, average intake is 23 mg/day
General
bioflavonoid; flavonoid
Database Correlations
PUBCHEM cid=5281672
References
- Wikipedia: Myricetin
https://en.wikipedia.org/wiki/Myricetin
- PubChem: 5281672
- McNamara D
First Evidence Dietary Flavonols Linked to Lower Alzheimer Risk.
Medscape - Jan 30, 2020.
https://www.medscape.com/viewarticle/9245
- George J
Flavonols Linked to Slower Cognitive Decline.
Memory scores better in older adults who ate more flavonol-rich fruits and vegetables.
MedPage Today November 23, 2022
https://www.medpagetoday.com/neurology/dementia/101921
- Holland TM, Agarwal P, Wang Y et al
Association of Dietary Intake of Flavonols With Changes in Global Cognition and
Several Cognitive Abilities.
Neurology. November 22, 2022
PMID: 36414424
https://n.neurology.org/content/early/2022/11/22/WNL.0000000000201541