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myozenin-3 (calsarcin-3, FATZ-related protein 3, MYOZ3, FRP3)
Function:
- myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere
- role in modulation of calcineurin signaling
- may play a role in myofibrillogenesis
- interacts with ACTN2, LDB3, FLNC, PPP3CA & TCAP
Structure: belongs to the myozenin family
Compartment: localized at the Z-line of skeletal muscle (putative)
Alternative splicing: named isoforms=3
Expression:
- expressed specifically in skeletal muscle
- not detected in heart
General
myozenin (MYOZ)
Properties
SIZE: MW = 27 kD
entity length = 251 aa
COMPARTMENT: cytoplasm
MOTIF: binding site
SITE: 50-67
FOR-BINDING-OF: alpha-actinin-2
calcineurin A-alpha
telethonin
binding site
SITE: 67-110
FOR-BINDING-OF: filamin C
binding site
SITE: 186-207
FOR-BINDING-OF: alpha-actinin-2
Database Correlations
UniProt Q8TDC0
Pfam PF05556
References
UniProt :accession Q8TDC0