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myozenin-2 (calsarcin-1, FATZ-related protein 2, MYOZ2, C4orf5)
Function:
- myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere
- role in modulation of calcineurin signaling
- role in myofibrillogenesis
- interacts via its C-terminus with spectrin repeats 3 & 4 of ACTN2
- interacts with ATCN1, LDB3, MYOT & PPP3CA
Structure:
- belongs to the myozenin family
Compartment:
- colocalizes with ACTN1 & PPP3CA at the Z-line of heart & skeletal muscle
Expression: expressed specifically in heart & skeletal muscle
General
myozenin (MYOZ)
Properties
SIZE: MW = 30 kD
entity length = 264 aa
COMPARTMENT: cytoplasm
Database Correlations
OMIM 605602
UniProt Q9NPC6
Pfam PF05556
References
UniProt :accession Q9NPC6