myozenin-1 (calsarcin-2, filamin-, actinin- & telethonin-binding protein, protein FATZ, MYOZ1, MYOZ)

Function: - myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP & localizing calcineurin signaling to the sarcomere - role in modulation of calcineurin signaling - role in myofibrillogenesis - interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA & TCAP - interacts via its C-terminal region with MYOT Structure: - belongs to the myozenin family Compartment: - localized to nucleus & pseudopodia of undifferentiated cells - detected throughout myotubes of differentiated cells - colocalizes with ACTN2, FLNC & MYOT at the Z-lines of skeletal muscle Expression: - expressed primarily in skeletal muscle - detected at lower levels in heart, prostate & pancreas

Properties

SIZE: MW = 32 kD entity length = 299 aa COMPARTMENT: cell nucleus MOTIF: glycine-rich region {95-175}

Database Correlations

OMIM 605603 UniProt Q9NP98 Pfam PF05556

References

UniProt :accession Q9NP98