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myogenic factor MYF-6; herculin; myogenic factor 6 (MYF6)
Function:
- role in muscle differentiation (myogenic factor)
- induces fibroblasts to differentiate into myoblasts
- probable sequence specific DNA-binding protein
- efficient DNA binding requires dimerization with another bHLH protein
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression: Skeletal muscle
Pathology:
- defects in MYF6 may be a cause of autosomal dominant myotubular myopathy
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: entity length = 242 aa
MW = 27 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 93-105
helix-loop-helix
NAME: helix-loop-helix
SITE: 106-145
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM correlations
MORBIDMAP 159991
UniProt P23409
PFAM correlations
Entrez Gene 4618
Kegg hsa:4618
References
- UniProt :accession P23409
- Entrez Gene :accession 4618