myocardin (MYOCD, MYCD)

Function: - transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence - binds CArG boxes only in the presence of serum response factor (SRF) - acts as a cofactor of SRF & modulates SRF-target genes - regulates expression of a set of cardiac & smooth muscle- specific genes - role in cardiogenesis & differentiation of the smooth muscle cell lineage (putative) - homodimer - interacts with SRF; its association does not depend on specific DNA sequences for ternary complex formation - interacts with MLLT7/FOXO4 Structure: - the C-terminal region contains a general transcription activation domain - the N-terminal region, comprising a basic domain & a Gln-rich domain, confers transcriptional potency & specificity by mediating association with the MADS box of SRF - the basic domain may be required for nuclear localization - the SAP domain is important for transactivation & ternary complex formation - contains 3 RPEL repeats - contains 1 SAP domain Compartment: nucleus (putative) Alternative splicing: named isoforms=3 Expression: - expressed in heart, aorta, & in smooth muscle cell- containing tissues: stomach, bladder, small intestine, colon, lung, placenta & uterus - very faint expression in prostate & skeletal muscle

Properties

SIZE: entity length = 938 aa MW = 102 kD COMPARTMENT: cell nucleus MOTIF: RPEL {18-43} RPEL {62-87} RPEL {106-131} glutamine-rich region {291-322} MOTIF: glutamine residue (SEVERAL) SAP {371-405} serine-rich region {435-508} MOTIF: serine residue (SEVERAL) coiled coil {516-561}

Database Correlations

OMIM 606127 UniProt Q8IZQ8 PFAM correlations Entrez Gene 93649

References

UniProt :accession Q8IZQ8