myeloid cell nuclear differentiation antigen (MNDA)

Function: - may act as a transcriptional activator/repressor in the myeloid lineage - plays a role in the granulocyte/monocyte cell-specific response to interferon - stimulates the DNA binding of the transcriptional repressor protein YY1 - participates in a ternary complex with YY1 & the YY1 target DNA element - binds nucleolin & nucleophosmin/NPM/B23 Structure: - its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding & a portion of this sequence is responsible for binding YY1 - contains 1 DAPIN domain - contains 1 HIN-200 domain Compartment: - nucleus, cytoplasm - uniformly distributed throughout the interphase cell nucleus - associates with chromatin Expression: - expressed constitutively in cells of the myeloid lineage - found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes & granulocytes - also appear in myeloblast cells in some cases of acute myeloid Leukemia - strongly induced by alpha interferon which selectively affects expression in late stage cells in monocytic but not granulocytic lineage - induced in vitro by 1,25 dihydroxyvitamin D3 & dimethylsulfoxide

Properties

SIZE: entity length = 407 aa MW = 46 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: DAPIN domain {1-88} nuclear translocation signal {131-137} HIN-200 domain {196-394}

Database Correlations

OMIM 159553 UniProt P41218 PFAM correlations Entrez Gene 4332 Kegg hsa:4332

References

swiss-prot P41218