myelin transcription factor 1-like protein; MyT1-L; MyT1L (MYT1L, KIAA1106)

Function: - may function as a panneural transcription factor associated with neuronal differentiation - may play a role in the development of neurons & oligodendrogalia in the CNS Structure: contains 6 C2HC-type zinc fingers Compartment: nucleus (putative) Alternative splicing: named isoforms=4 Pathology: - defects in MYT1L are the cause of mental retardation, autosomal dominant 39

General

human longevity protein nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: MW = 133 kD entity length = 1186 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2HC-type SITE: 28-58 EFFECTOR-BOUND: Zn+2 acidic region {97-169} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S250} Zn finger C2HC-type SITE: 503-533 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 547-577 EFFECTOR-BOUND: Zn+2 serine-rich region {686-719} MOTIF: serine residue (SEVERAL) Zn finger C2HC-type SITE: 902-932 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 951-981 EFFECTOR-BOUND: Zn+2 Zn finger C2HC-type SITE: 1004-1034 EFFECTOR-BOUND: Zn+2 coiled coil {1056-1130}

Database Correlations

OMIM correlations UniProt Q9UL68 PFAM correlations Entrez Gene 23040 Kegg hsa:23040

References

UniProt :accession Q9UL68