myelin protein zero-like protein 1 (protein zero-related, MPZL1, PZR, UNQ849/PRO1787)

Function: 1) cell surface receptor 2) signal transduction processes 3) recruits PTPN11/SHP-2 to the cell membrane 4) putative substrate of PTPN11/SHP-2 5) receptor for concanavalin A (ConA) a) cellular signaling induced by ConA b) induces Src family tyrosine- protein kinases c) isoform 3 with dominant negative role - blocks tyrosine phosphorylation of MPZL1 induced by ConA 6) integrin-mediated cell motility (isoform 1 only) 7) interacts with phosphorylated PTPN11/SHP-2 8) contains ITIM motifs 9) phosphorylated on TYR upon stimulation with pervanadate & concanavalin A (ConA) 10) phosphorylation at Tyr-241 & Tyr-263 is required for interaction with PTPN11/SHP-2. 11) dephosphorylated by PTPN11/SHP-2 (in vitro) Alternative splicing: named isoforms=4 Expression: - widely expressed - highest levels in heart, placenta, kidney, pancreas

General

cell surface receptor glycoprotein phosphoprotein

Properties

SIZE: MW = 29 kD entity length = 269 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-35} immunoglobulin superfamily domain {36-146} MOTIF: cysteine residue {C58} MODIFICATION: cysteine residue {C135} N-glycosylation site {N130} cysteine residue {C135} MODIFICATION: cysteine residue {C58} transmembrane domain {163-183} immunoreceptor tyrosine-based inhibitory motif (ITIM) {239-244} MOTIF: Tyr phosphorylation site {Y241} immunoreceptor tyrosine-based inhibitory motif (ITIM) {261-266} MOTIF: Tyr phosphorylation site {Y263}

Database Correlations

OMIM 604376 UniProt O95297 Pfam PF07686

References

UniProt :accession O95297