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Myc target protein 1 (Myc target in myeloid cells protein 1, MYCT1, MTLC, MTMC1)
Function:
- may regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator
- does not seem to significantly affect cell growth
- overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, & inhibition of hematopoietic differentiation (putative)
Structure: belongs to the MYCT1 family
Compartment:
- nucleus
- expressed in nuclei ofhepatocellular carcinoma cell line Bel7402 cells
Pathology:
- down-regulated in gastric cancer tissues
Note: uncertain whether Met-1 or Met-49 is the initiator
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 235 aa
MW = 27 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {95-113}
Ser phosphorylation site {S135}
Ser phosphorylation site {S138}
Database Correlations
UniProt Q8N699
References
UniProt :accession Q8N699