MYC-induced nuclear antigen (Mineral dust-induced gene protein, nucleolar protein 52, MINA, MDIG, MINA53, NO52)

Function: - role in cellular proliferation - role in cell growth & survival - may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles Structure: contains 1 JmjC domain Compartment: nucleus, nucleus, nucleolus Alternative splicing: named isoforms=3 Expression: - expressed in liver, skeletal muscle, heart, pancreas, & placenta - t detected in brain, lung or kidney Pathology: - expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues - highly expressed in several esophageal squamous cell carcinoma & colon cancer tissues, & in various cancer cell lines - up-regulated in response to MYC, in alveolar macrophages from coal miners & in silica particle-treated A549 lung cancer cells

Properties

SIZE: entity length = 465 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: JmjC {139-271}

Database Correlations

UniProt Q8IUF8 Pfam PF08007

References

UniProt :accession Q8IUF8