Myc-associated zinc finger protein; MAZI; pur-1; purine-binding transcription factor; transcription factor Zif87; ZF87; zinc finger protein 801 (MAZ, ZNF801)

Function: - may function as a transcription factor with dual roles in transcription initiation & termination - binds to two sites, ME1a1 & ME1a2, within the MYC promoter - has greater affinity for ME1a1 - also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors - interacts with BPTF Structure: contains 6 C2H2-type Zn⁺² fingers Compartment: - nucleus (probable) Expression: - present in kidney, liver & brain - in the brain, highest levels are found in motor cortex & midfrontal cortex (at protein level) Pathology: - in brains of Alzheimer disease patients, present in plaque-like structures

General

C2H2 type zinc finger protein nuclear protein

Properties

SIZE: entity length = 477 aa MW = 49 kD COMPARTMENT: cell nucleus MOTIF: alanine-rich region {96-108} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 133-139 MOTIF: proline residue (SEVERAL) alanine-rich region {157-161} MOTIF: alanine residue (SEVERAL) Zn finger C2H2-type SITE: 190-212 EFFECTOR-BOUND: Zn+2 glycine-rich region {245-249} Zn finger C2H2-type SITE: 279-301 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 307-329 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 337-360 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 366-388 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 392-413 EFFECTOR-BOUND: Zn+2 alanine-rich region {435-449} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 600999 UniProt P56270 Pfam PF00096 Entrez Gene 4150 Kegg hsa:4150

References

UniProt :accession P56270