Myb-related protein p42POP; partner of profilin (P42POP, MYPOP)

Function: - transcriptional repressor - DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3' - dimerization with PFN1 reduces its DNA-binding capacity - interacts with PFN1 - homodimer & heterodimer with PFN1 Structure: - proline-rich region is required for PFN1 interaction - contains 1 Myb-like domain Compartment: nucleus (putative)

General

DNA-binding protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 399 aa MW = 43 kD COMPARTMENT: cell nucleus MOTIF: Myb-like {12-84} nuclear translocation signal {83-86} proline-rich region SITE: 136-380 MOTIF: proline residue (SEVERAL) nuclear translocation signal {382-385} nuclear translocation signal {390-393}

Database Correlations

UniProt Q86VE0 Kegg hsa:3393

References

UniProt :accession Q86VE0