MutS-beta

Function: - binds to insertion/deletion mispairs but shows little to no affinity for base-base mismatches Structure: - complex of msh2 & msh3 proteins

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: DNA mismatch repair protein Msh2 MOTIF: EXO1 interaction {601-671} ATP-binding site NAME: ATP-binding site SITE: 669-676 binding site EFFECTOR-BOUND: DNA mismatch repair protein Msh3 Ser phosphorylation site {S860} DNA mismatch repair protein Msh3 MOTIF: alanine-rich region {51-62} MOTIF: alanine residue (SEVERAL) EXO1 interaction {75-297} MOTIF: Ser phosphorylation site {S201} binding site EFFECTOR-BOUND: DNA mismatch repair protein Msh2 ATP-binding site NAME: ATP-binding site SITE: 896-903 Tyr phosphorylation site {Y1068}

References

Modrich. J Biol Chem 272:24727-30, 1997

Components

DNA mismatch repair protein Msh2; hMSH2; mutS protein homolog 2 (MSH2) DNA mismatch repair protein Msh3; MutS holomolog 3; divergent upstream protein; DUP; mismatch repair protein 1; MRP1 (MSH3, DUC1, DUG)