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MutS-alpha
Function:
- GT mismatch-binding protein (p160GTBP) forms a complex with MSH2 protein at sites of single base mispairs or slipped intermediates of single base runs [1]
Interactions
molecular events
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: DNA mismatch repair protein Msh2
MOTIF: EXO1 interaction {601-671}
ATP-binding site
NAME: ATP-binding site
SITE: 669-676
binding site
EFFECTOR-BOUND: DNA mismatch repair protein Msh6
Ser phosphorylation site {S860}
DNA mismatch repair protein Msh6
MOTIF: Ser phosphorylation site {S14}
alanine-rich region {34-37}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S41}
Ser phosphorylation site {S43}
Ser phosphorylation site {S79}
Ser phosphorylation site {S91}
PWWP domain {92-154}
MOTIF: Ser phosphorylation site {S137}
Thr phosphorylation site {T139}
Ser phosphorylation site {S200}
glutamate-rich region {201-209}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S219}
Ser phosphorylation site {S227}
Ser phosphorylation site {S252}
Ser phosphorylation site {S254}
Ser phosphorylation site {S256}
Ser phosphorylation site {S261}
Ser phosphorylation site {S309}
Ser phosphorylation site {S348}
Ser phosphorylation site {S830}
Thr phosphorylation site {T924}
binding site
EFFECTOR-BOUND: DNA mismatch repair protein Msh2
glutamate-rich region {1118-1123}
MOTIF: glutamate residue (SEVERAL)
ATP-binding site
NAME: ATP-binding site
SITE: 1134-1141
References
- Karran P.
Appropriate partners make good matches.
Science. 1995 Jun 30;268(5219):1857-8. Review.
PMID: 7604258
Components
DNA mismatch repair protein Msh2; hMSH2; mutS protein homolog 2 (MSH2)
DNA mismatch repair protein Msh6; hMSH6; mutS-alpha 160 kD subunit; p160; G/T mismatch-binding protein; GTMBP; GTBP (MSH6 GTBP)