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MutL-alpha
MLH1 protein forms a complex with PMS2 protein [1].
Interactions
molecular events
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: DNA mismatch repair protein Mlh1
MOTIF: EXO1 interaction {410-650}
MOTIF: Ser phosphorylation site {S477}
binding site
EFFECTOR-BOUND: Mismatch repair endonuclease PMS2
Mismatch repair endonuclease PMS2
MOTIF: Tyr phosphorylation site {Y181}
Ser phosphorylation site {S403}
Thr phosphorylation site {T573}
binding site
EFFECTOR-BOUND: DNA mismatch repair protein Mlh1
References
- Karran P.
Appropriate partners make good matches.
Science. 1995 Jun 30;268(5219):1857-8. Review.
PMID: 7604258
Components
DNA mismatch repair protein Mlh1; mutL protein homolog 1 (MLH1, COCA2)
Mismatch repair endonuclease PMS2; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; postmeiotic segregation increased-2 (PMS2, PMSL2)